Duyệt theo

Hồ sơ tác giả

Tìm kiếm theo: Chủ đề GTPase

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Hoặc nhập chữ cái đầu tiên:  
Hiển thị kết quả tìm kiếm từ 1 đến 3 trong 3 kết quả phù hợp
  • OER000004017.pdf.jpg
  • Journal article

  • A non-linear system patterns Rab5 GTPase on the membrane

    • Tác giả : A, Cezanne; J, Lauer; A, Solomatina (2019)

  • Proteins can self-organize into spatial patterns via non-linear dynamic interactions on cellular membranes. Modelling and simulations have shown that small GTPases can generate patterns by coupling guanine nucleotide exchange factors (GEF) to effector binding, generating a positive feedback of GTPase activation and membrane recruitment. Here, we reconstituted the patterning of the small GTPase Rab5 and its GEF/effector complex Rabex5/Rabaptin5 on supported lipid bilaye...
  • OER000002600.pdf.jpg
  • Journal article

  • Mechanism of GTPase activation of a prokaryotic small Ras-like GTPase MglA by an asymmetrically interacting MglB dimer

    • Tác giả : Chakraborty, Sukanya (2023)

  • Cell polarity oscillations in Myxococcus xanthus motility are driven by a prokaryotic 23 small Ras-like GTPase, MglA, which switches from one cell pole to the other in 24 response to extracellular signals. MglA dynamics is regulated by MglB, which 25 functions both as a GAP (GTPase activating protein) and a GEF (guanine nucleotide 26 exchange factor) for MglA. With an aim to dissect the role of asymmetry in the dual ...
  • OER000000897.pdf.jpg
  • Journal article

  • RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway

    • Tác giả : Thillaivillalan, Dhanaraman; Singh, Swati; Killoran, Ryan C (2020)

  • Activated RAS GTPases signal by directly binding effector proteins. Effectors have a folded RAS association (RA) domain that binds exclusively to GTP-loaded RAS, but the specificity of most RA domains for >150 RAS superfamily GTPases is unknown. Ten RAS-association domain family (RASSF) proteins comprise the largest group of effectors, proposed to couple RAS to the pro-apoptotic Hippo pathway. We show that RASSF1-6 complex ...