Duyệt theo

Hồ sơ tác giả

Tìm kiếm theo: Chủ đề Gen

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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  • OER000000145.pdf.jpg
  • Professional Practice Paper

  • HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase Johannes

    • Tác giả : Rudolph, Johannes (2020)

  • Poly(ADP-ribose) polymerase 1 (PARP1) is an important player in the response to DNA damage. Recently, histone PARylation factor (HPF1) was shown to be a critical modulator of the activity of PARP1 by facilitating PARylation of histones and redirecting the target amino acid specificity from acidic to serine residues. Here we investigate the mechanism and specific consequences of HPF1-mediated PARylation using nucleosomes as both activators and substrates for&#...