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Browsing by Subject Glycosylation

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  • OER000000247.pdf.jpg
  • Journal article

  • ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs

    • Authors : Zolotarov, Yevgen; González-Recio, Irene; Ma, Chao (2020)

  • Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg2+) homeostasis. Using various biochemical approaches, we have identified members of the CNNM family as direct interacting partners of ADP-ribosylation factor-like protein 15 (ARL15), a small GTP-binding protein. ARL15 interacts with CNNMs at their carboxyl-terminal conserved cystathionine-β-synthase (CBS) domains. In silico modeling of the interaction using the reported structures of both CNNM2 and ARL15 s...
  • OER000000807.pdf.jpg
  • Journal article

  • Measuring site-specific glycosylation similarity between influenza A virus variants with statistical certainty

    • Authors : Chang, Deborah; Hackett, William E; Zhong, Lei (2020)

  • Influenza A virus (IAV) mutates rapidly, resulting in antigenic drift and poor year-to-year vaccine effectiveness. One challenge in designing effective vaccines is that genetic mutations frequently cause amino acid variations in IAV envelope protein hemagglutinin (HA) that create new N-glycosylation sequons; resulting N-glycans cause antigenic shielding, allowing viral escape from adaptive immune responses. Vaccine candidate strain selection currently involves correlating antigenicity...