Journal articleAuthors : Seth, Anubha (2023)
Nine mammalian adenylyl cyclases (AC) are pseudoheterodimers with two hexahelical 29 membrane domains which are isoform-specifically conserved. Previously we proposed that these 30 membrane domains are orphan receptors (10.7554/eLife.13098; 10.1016/j.cellsig.2020.109538). 31 Lipids extracted from fetal bovine serum at pH 1 inhibited several mAC activities. Guided by a 32 lipidomic analysis we tested glycerophospholipids as potential ligands. Contrary to expectations 33 we s... 
