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Showing results 1 to 4 of 4
  • OER000002659.pdf.jpg
  • Journal article

  • Biochemical Properties of Naturally Occurring Human Bloom Helicase Variants

    • Authors : Cueny, Rachel R. (2023)

  • Bloom syndrome helicase (BLM) is a RecQ-family helicase implicated in a variety of cellular 24 processes, including DNA replication, DNA repair, and telomere maintenance. Mutations in 25 human BLM cause Bloom syndrome (BS), an autosomal recessive disorder that leads to myriad 26 negative health impacts including a predisposition to cancer. BS-causing mutations in BLM 27 often negatively impact BLM ATPase and helicase activity. While BLM mut...
  • OER000000722.pdf.jpg
  • Journal article

  • The Hrq1 helicase stimulates Pso2 translesion nuclease activity to promote DNA inter-strand crosslink repair

    • Authors : Rogers, Cody M; Lee, Chun-Ying; Parkins, Samuel (2020)

  • DNA inter-strand crosslink (ICL) repair requires a complicated network of DNA damage response pathways. Removal of these lesions is vital as they are physical barriers to essential DNA processes that require the separation of duplex DNA, such as replication and transcription. The Fanconi anemia (FA) pathway is the principle mechanism for ICL repair in metazoans and is coupled to replication. In Saccharomyces cerevisiae, a degenerate FA pathway is pr...
  • OER000000190.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader

    • Authors : Puri, Neha (2020)

  • To dissect how specific ATPase elements of E. coli DnaC, an archetypal loader for the bacterial DnaB helicase, play distinct roles in helicase loading and the activation of DNA unwinding. We identify a new element, the arginine-coupler, which regulates the switch-like behavior of DnaC to prevent futile ATPase cycling and maintains loader responsiveness to replication restart systems. Our data help explain how the ATPase cycle of a AAA+-family helica...
  • OER000004025.pdf.jpg
  • Journal article

  • The TFIIH subunits p44/p62 act as a damage sensor during nucleotide excision repair

    • Authors : JT, Barnett; J, Kuper; W, Koelmel (2019)

  • Nucleotide excision repair (NER) protects the genome following exposure to diverse types of DNA damage, including UV light and chemotherapeutics. Mutations in mammalian NER genes lead to diseases such as xeroderma pigmentosum, trichothiodystrophy, and Cockayne syndrome. In eukaryotes, the major transcription factor TFIIH is the central hub of NER. The core components of TFIIH include the helicases XPB, XPD, and five ‘structural’ subunits. Two of these structu...