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  • OER000000847.pdf.jpg
  • Journal article

  • Differential glycosylation of alpha-1-acid glycoprotein (AGP-1) contributes to its functional diversity

    • Authors : Sumanth, Mosale Seetharam; Jacob, Shancy P; Abhilasha, Kandahalli Venkataranganayaka (2020)

  • Alpha-1-acid glycoprotein (AGP-1) is a positive acute phase glycoprotein with uncertain functions. Serum AGP-1 (sAGP-1) is primarily derived from hepatocytes and circulates as 12 to 20 different glycoforms. We isolated a glycoform secreted from stimulated human neutrophils (nAGP-1). Its peptide sequence was identical to hepatocyte-derived sAGP-1, but nAGP-1 differed from sAGP-1 in its chromatographic behaviour, electrophoretic mobility, and glycosylation. The function of these&#...
  • OER000000727.pdf.jpg
  • Journal article

  • Naringenin downregulates inflammation-mediated nitric oxide overproduction and potentiates endogenous antioxidant status during hyperglycemia

    • Authors : Rehman, Kanwal; Khan, Ikram Ilahee; Akash, Muhammad Sajid Hamid (2020)

  • Nitric oxide (NO) is a key regulating factor for physiological functions, when elevated during inflammatory conditions can lower endogenous antioxidant levels. Increased NO interacts with oxygen or other ROS to generate peroxynitrite, a potent oxidant which induces oxidative stress. Analgesic effects of naringenin (NRN), a flavanone has been demonstrated by inducing anti-inflammatory effects in O2−•-mediated inflammation. NRN stimulates antioxidant enzymes and also improves ...