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  • OER000000243.pdf.jpg
  • Journal article

  • Human trans-editing enzyme displays tRNA acceptor stem specificity and relaxed amino acid selectivity

    • Authors : Vargas-Rodriguez, Oscar; Bakhtina, Marina; McGowan, Daniel (2020)

  • Accurate translation of genetic information into proteins is vital for cell sustainability. ProXp-ala prevents proteome-wide Pro-to-Ala mutations by hydrolyzing misacylated Ala-tRNAPro, which is synthesized by prolyl-tRNA synthetase (ProRS). Bacterial ProXp-ala was previously shown to combine a size-based exclusion mechanism with conformational and chemical selection for the recognition of the alanyl moiety, while tRNAPro is selected via recognition of tRNA acceptor stem elements...