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  • OER000002665.pdf.jpg
  • Journal article


  • Authors : Eymery, Mathias C. (2023)

  • Autotaxin is primarily known for the formation of lysophosphatidic acid (LPA) from 22 lysophosphatidylcholine (LPC). LPA is an important signaling phospholipid that can bind to six 23 G-protein coupled receptors (LPA1-6). The ATX-LPA signaling axis is a critical component in 24 many physiological and pathophysiological conditions. Here, we describe a potent inhibition 25 of Δ9-trans-tetrahydrocannabinol (THC), the main psychoactive compound of medicinal &...

  • OER000002708.pdf.jpg
  • Journal article


  • Authors : Dhingra, Yukti (2023)

  • Adaptation in CRISPR-Cas systems immunizes bacteria and archaea against mobile genetic 10 elements. In many DNA-targeting systems, the Cas4-Cas1-Cas2 complex is required for selection 11 and processing of DNA segments containing PAM sequences, prior to integration of these 12 “prespacer” substrates as spacers in the CRISPR array. We determined cryo-EM structures of the 13 Cas4-Cas1-Cas2 adaptation complex from the type I-C system that encodes st...