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  • OER000000720.pdf.jpg
  • Journal article

  • Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes

    • Authors : Montemayor, Eric J; Virta, Johanna M; Hayes, Samuel M (2020)

  • Eukaryotes possess eight highly conserved Lsm (like Sm) proteins that assemble into circular, heteroheptameric complexes, bind RNA, and direct a diverse range of biological processes. Among the many essential functions of Lsm proteins, the cytoplasmic Lsm1-7 complex initiates mRNA decay, while the nuclear Lsm2-8 complex acts as a chaperone for U6 spliceosomal RNA. It has been unclear how these complexes perform their distinct functions while differing by ...