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  • OER000000726.pdf.jpg
  • Journal article

  • Affinity proteomic dissection of the human nuclear cap-binding complex interactome

    • Authors : Dou, Yuhui; Kalmykova, Svetlana; Pashkova, Maria (2020)

  • A 5’, 7-methylguanosine cap is a quintessential feature of RNA polymerase II-transcribed RNAs, and a textbook aspect of co-transcriptional RNA processing. The cap is bound by the cap-binding complex (CBC), canonically consisting of nuclear cap-binding proteins 1 and 2 (NCBP1/2). The CBC has come under renewed investigative interest in recent years due to its participation in RNA-fate decisions via interactions with RNA productive factors as well as ...
  • OER000000638.pdf.jpg
  • Journal article

  • Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signaling networks using SILAC-based phosphoproteomics

    • Authors : Byrne, Dominic P; Clarke, Christopher J; Brownridge, Philip J (2020)

  • Polo-like kinase 4 (PLK4) is the master regulator of centriole duplication in metazoan organisms. Catalytic activity and protein turnover of PLK4 are tightly coupled in human cells, since changes in PLK4 concentration and catalysis have profound effects on centriole duplication and supernumerary centrosomes, which are associated with aneuploidy and cancer. Recently, PLK4 has been targeted with a variety of small molecule kinase inhibitors exemplified by centrinone...