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  • OER000000867.pdf.jpg
  • Journal article

  • Revealing dynamic protein acetylation across subcellular compartments

    • Authors : Baeza, Josue; Lawton, Alexis J; Fan, Jing (2020)

  • Protein acetylation is a widespread post-translational modification implicated in many cellular processes. Recent advances in mass spectrometry have enabled the cataloging of thousands of sites throughout the cell, however identifying regulatory acetylation marks have proven to be a daunting task. Knowledge of the kinetics and stoichiometry of site-specific acetylation are important factors to uncover function. Here, an improved method of quantifying acetylation stoichiometry&#x...
  • OER000000843.pdf.jpg
  • Journal article

  • Uncyclized xanthommatin is a key ommochrome intermediate in invertebrate coloration

    • Authors : Figon, Florent; Munsch, Thibaut; Croix, Cécile (2020)

  • Ommochromes are widespread pigments that mediate multiple functions in invertebrates. The two main families of ommochromes are ommatins and ommins, which both originate from the kynurenine pathway but differ in their backbone, thereby in their coloration and function. Despite its broad significance, how the structural diversity of ommochromes arises in vivo has remained an open question since their first description. In this study, we combined organic synthes...