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Browsing by Subject Membrane Protein Folding

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  • OER000000936.pdf.jpg
  • Journal article

  • Cotranslational Folding Stimulates Programmed Ribosomal Frameshifting in the Alphavirus Structural Polyprotein

    • Authors : Harrington, Haley R; Zimmer, Matthew H; Chamness, Laura M (2020)

  • Viruses maximize their genetic coding capacity through a variety of biochemical mechanisms including programmed ribosomal frameshifting (PRF), which facilitates the production of multiple proteins from a single transcript. PRF is typically stimulated by structural elements within the mRNA that generate mechanical tension between the transcript and ribosome. However, in this work we show that the forces generated by the cotranslational folding of the nascent polypeptide...
  • OER000000703.pdf.jpg
  • Journal article

  • Molecular Basis for the Evolved Instability of a Human G-Protein Coupled Receptor

    • Authors : Chamness, Laura M; Zelt, Nathan B; Kuntz, Charles P (2020)

  • Membrane proteins are prone to misfolding and degradation. This is particularly true for mammalian forms of the gonadotropin-releasing hormone receptor (GnRHR). Though they function at the plasma membrane, mammalian GnRHRs tend to accumulate within the secretory pathway. Their apparent instability is believed to have evolved in response to selection for attenuated GnRHR activity. Nevertheless, the structural basis of this adaptation remains unclear. We find that t...