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  • OER000000792.pdf.jpg
  • Journal article

  • Integrated metabolomics and proteomics of symptomatic and early pre-symptomatic states of colitis

    • Authors : Shimshoni, Elee; Ghini, Veronica; Solomonov, Inna (2020)

  • Two murine models for colitis were used to study multi-level changes and derive molecular signatures of colitis onset and development. By combining metabolomics data on tissues and fecal extracts with proteomics data on tissues, we provide a comprehensive picture of the metabolic profile of acute and chronic states of the disease, and most importantly, of two early pre-symptomatic states. We show that, increased anaerobic glycolysis, accompanied by alter...
  • OER000000736.pdf.jpg
  • Journal article

  • Studies in alkaptonuria reveal new roles beyond drug clearance for phase I and II biotransformations in tyrosine metabolism

    • Authors : Norman, Brendan P; Davison, Andrew S; Hughes, Juliette H (2020)

  • AKU is rare, but our findings further what is currently understood about tyrosine metabolism more generally, and show for the first time that phase I and II detoxification is recruited to prevent accumulation of endogenously-produced metabolites in inborn errors of metabolism. The data highlight the misconception that phase I and II metabolic biotransformations are reserved solely for drug clearance; these are ancient mechanisms, which represent new potential...