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Showing results 1 to 4 of 4
  • OER000000921.pdf.jpg
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  • Application of petri nets methodoloydy for the examination of the bio(physico)chemical parameters of mitochodria funtioning

    • Authors : Danylovych, Hanna V; Chunikhin, Alexander Yu; Danylovych, Yuriy V (2020)

  • A mathematical model is developed using Petri net methodology that is able to predict simultaneous changes in bio(physical)chemical parameters of mitochondria, namely hydrodynamic diameter, fluorescence of NADH, DCF fluorescence signal depending on the time of action and concentration of sodium azide and predict these changes for unknown NaN3 concentration. The model is created for real experimental conditions, it combines functional changes of mitochondria with a ...
  • OER000000863.pdf.jpg
  • Journal article

  • Assessment of mitochondrial physiology of murine white adipose tissue by mechanical permeabilization and lipid depletion

    • Authors : Romeiro, Natália C; Ferreira, Caroline M; Oliveira, Marcus F (2020)

  • White adipose tissue (WAT) is classically associated with energy storage in the form of triacylglycerol and is directly associated with metabolic disorders, including obesity. Mitochondria regulates cellular expenditure and are active in WAT. Although isolated mitochondria have been classically used to assess their functions, several artifacts can be introduced by this approach. Although methods to assess mitochondrial physiology in permeabilized WAT were proposed, importan...
  • OER000000214.pdf.jpg
  • Journal article

  • HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia

    • Authors : Laquatra, Claudio; Martin, Carlos Sanchez; Minervini, Giovanni (2020)

  • TRAP1 is highly expressed in the early stages of Zebrafish development, and its ablation delays embryogenesis while increasing mitochondrial respiration of fish larvae. TRAP1 expression is enhanced by hypoxic conditions both in developing embryos and in cancer models of Zebrafish and mammals. The TRAP1 promoter contains evolutionary conserved hypoxic responsive elements, and HIF1 stabilization increases TRAP1 levels. TRAP1 inhibition by selective compounds or by genet...
  • OER000000408.pdf.jpg
  • Journal article

  • Mitochondrial fatty acid synthesis coordinates mitochondrial oxidative metabolism

    • Authors : Nowinski, Sara M; Solmonson, Ashley; Rusin, Scott F (2020)

  • Cells harbor two systems for fatty acid synthesis, one in the cytoplasm (catalyzed by fatty acid synthase, FASN) and one in the mitochondria (mtFAS). In contrast to FASN, mtFAS is poorly characterized, especially in higher eukaryotes, with the major product(s), metabolic roles, and cellular function(s) being essentially unknown. Here we show that hypomorphic mtFAS mutants display a severe loss of electron transport chain (ETC) complexes and exhibit compe...