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  • OER000002709.pdf.jpg
  • Journal article

  • Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro

    • Authors : Yadav, Ruchi (2023)

  • SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 34 pandemic. Its ~30 kb RNA genome is translated into two large polyproteins subsequently cleaved 35 by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processing is essential 36 yet incompletely understood. We studied Mpro-mediated processing of the nsp7-10/11 37 polyprotein, whose mature products are cofactors of the viral replicase, identifying the&#...
  • OER000002970.pdf.jpg
  • Journal article

  • Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease

    • Authors : MacDonald, Elizabeth A. (2021)

  • The main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease (COVID-19), is an ideal target for pharmaceutical inhibition. It is required for infection, it cleaves the viral polyprotein at multiple sites, and it is conserved among coronaviruses and distinct from human proteases. We present crystal structures of SARS CoV-2 Mpro bound to two viral substrate peptides. The structures show how Mpro...