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Browsing by Subject Nitrogenase-like enzymes

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  • OER000000768.pdf.jpg
  • Journal article

  • Substrate sensing institutes sequential and asymmetric electron transfer in the nitrogenase-like DPOR complex

    • Authors : Corless, Elliot I; Bennett, Brian; Antony, Edwin (2020)

  • Dark-operative protochlorophyllide oxidoreductase (DPOR) catalyzes the reduction of protochlorophyllide (Pchlide) to chlorophyllide (Chlide), a key penultimate step in the biosynthesis of bacteriochlorophyll. DPOR shares structural homology with nitrogenase and is made of electron donor (BchL) and electron acceptor (BchNB) component proteins. ATP driven assembly of the BchL and BchNB proteins drives electron transfer and Pchlide reduction. BchNB is composed of two subunits each&...
  • OER000004058.pdf.jpg
  • Journal article

  • The flexible N-terminus of BchL protects its [4Fe-4S] cluster in oxygenic environments and autoinhibits activity

    • Authors : Corless, Elliot; Imran, Syed Muhammad Saad; Watkins, Maxwell B (2019)

  • It is propose that ATP-binding produces a conformational compaction of the BchL homodimer leading to a release of the flexible N-terminus from blocking the [4Fe-4S] cluster and promotes complex formation with BchNB to drive electron transfer. The auto-inhibitive feature and release mechanism appear unique to DPOR and is not found in the structurally similar nitrogenase.