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  • OER000000265.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • A clinically-relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position

    • Authors : Ruggiero, Melissa J; Malhotra, Shipra (2020)

  • Conventionally, most amino acid substitutions at important protein positions are expected to abolish function. However, in several soluble-globular proteins, we identified a class of non-conserved positions for which various substitutions produced progressive functional changes; we consider these evolutionary “rheostats”. Here, we report a strong rheostat position in the integral membrane protein, Na+/taurocholate cotransporting polypeptide (NTCP), at the site of a pharmacologically-...
  • OER000000400.pdf.jpg
  • Journal article

  • Dynamic regulation of translation quality control associated with ribosome stalling

    • Authors : Goldman, Daniel H; Livingston, Nathan M; Movsik, Jonathan (2020)

  • Translation of problematic mRNA sequences induces ribosome stalling. Collided ribosomes at the stall site are recognized by cellular quality control machinery, resulting in dissociation of the ribosome from the mRNA and subsequent degradation of the nascent polypeptide and in some organisms, decay of the mRNA. However, the timing and regulation of these processes are unclear. We developed a SunTag-based reporter to monitor translation in real time on sin...