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Browsing by Subject Post-translational modifications

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  • OER000000759.pdf.jpg
  • Journal article

  • A cooperative network of molecular “hot spots” highlights the complexity of LH3 collagen glycosyltransferase activities

    • Authors : Chiapparino, Antonella; Giorgi, Francesca De; Scietti, Luigi (2020)

  • Hydroxylysine glycosylations are collagen-specific post-translational modifications essential for maturation and homeostasis of fibrillar as well as non-fibrillar collagen molecules. Lysyl hydroxylase 3 (LH3) is the only human enzyme capable of performing two chemically-distinct collagen glycosyltransferase reactions using the same catalytic site: inverting beta-1,O-galactosylation of hydroxylysines and retaining alpha-1,2-glycosylation of galactosyl hydroxylysines. Here, we used structure-based mutagenesis ...
  • OER000000170.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Amphipathic Fluorescent Dyes for Sensitive and Long-Term Monitoring of Plasma Membranes

    • Authors : Daly, Leonard (2020)

  • Adaption of cells to low oxygen environments is an essential process mediated in part by the Hypoxia Inducible Factors (HIFs). Like other transcription factors, the stability and transcriptional activity of HIFs, and consequently he hypoxic response, are regulated by post-translational modification (PTM) and changes in biomolecular interactions. However, our current understanding of PTM-mediated regulation of HIFs is primarily based on in vitro protein fragment-based s...