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Showing results 1 to 6 of 6
  • OER000000799.pdf.jpg
  • Journal article

  • Convergent evolution of the Hedgehog/Intein fold in protein splicing

    • Authors : Beyer, Hannes M; Virtanen, Salla I; Aranko, A. Sesilja (2020)

  • The widely used molecular evolutionary clock assumes the divergent evolution of proteins. Convergent evolution has been proposed only for small protein elements but not for an entire protein fold. We investigated the structural basis of the protein splicing mechanism by class 3 inteins, which is distinct from class 1 and 2 inteins. We gathered structural and mechanistic evidence supporting the notion that the Hedgehog/INTein (HINT) superfamily fold, ...
  • OER000002696.pdf.jpg
  • Journal article

  • Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for SARS-CoV-2 3CL Protease

    • Authors : Hirose, Yuya (2023)

  • The pandemic of coronavirus disease 2019 (COVID-19) has urgently necessitated the development of antiviral agents against severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2). The 3C-like protease (3CLpro) is a promising target for COVID-19 treatment. Here, we report the new class of covalent inhibitors for 3CLpro possessing chlorofluoroacetamide (CFA) as a cysteine reactive warhead. Based on the aza-peptide scaffold, we synthesized the series...
  • OER000002970.pdf.jpg
  • Journal article

  • Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease

    • Authors : MacDonald, Elizabeth A. (2021)

  • The main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease (COVID-19), is an ideal target for pharmaceutical inhibition. It is required for infection, it cleaves the viral polyprotein at multiple sites, and it is conserved among coronaviruses and distinct from human proteases. We present crystal structures of SARS CoV-2 Mpro bound to two viral substrate peptides. The structures show how Mpro...