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  • OER000000651.pdf.jpg
  • Journal article

  • Alzheimer cells on their way to derailment show selective changes in protein quality control network

    • Authors : Koopman, Margreet B (2020)

  • Alzheimer’s Disease is driven by protein aggregation and is characterised by accumulation of Tau protein into neurofibrillary tangles. In healthy neurons the cellular protein quality control is successfully in charge of protein folding, which raises the question to which extent this control is disturbed in disease. Here we describe that brain cells in Alzheimer’s Disease show very specific derailment of the protein quality control network. We performed a...
  • OER000000703.pdf.jpg
  • Journal article

  • Molecular Basis for the Evolved Instability of a Human G-Protein Coupled Receptor

    • Authors : Chamness, Laura M; Zelt, Nathan B; Kuntz, Charles P (2020)

  • Membrane proteins are prone to misfolding and degradation. This is particularly true for mammalian forms of the gonadotropin-releasing hormone receptor (GnRHR). Though they function at the plasma membrane, mammalian GnRHRs tend to accumulate within the secretory pathway. Their apparent instability is believed to have evolved in response to selection for attenuated GnRHR activity. Nevertheless, the structural basis of this adaptation remains unclear. We find that t...