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Browsing by Subject Pseudomonas aeruginosa

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  • OER000000288.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Evaluation of ExoU inhibitors in a Pseudomonas aeruginosa scratch infection assay

    • Authors : Foulkes, Daniel M; McLean, Keri; Harris, Joscelyn (2020)

  • Pseudomonas aeruginosa has recently been highlighted by the World Health Organisation (WHO) as a major threat with high priority for the development of new therapies. The type III secretion system of P. aeruginosa delivers the toxin ExoU into the cytosol of target host cells, where its plasma membrane directed phospholipase activity induces rapid cell lysis. Therefore, inhibition of the phospholipase activity of ExoU would be an important treatment ...
  • OER000002998.pdf.jpg
  • Journal article

  • Intrinsic Degradation of the Type-II Antitoxin ParD from Pseudomonas aeruginosa

    • Authors : Snead, Kevin J. (2021)

  • Type-II Toxin Antitoxin (TA) systems are regulated by differential half-lives of the resulting non-secreted proteins, such that the neutralizing antitoxin undergoes continual degradation and replenishment to maintain neutralization of its cognate toxin. Antitoxin proteins are widely reported as labile, including upon purification and in vitro storage. During the course of studies on a ParDE TA system we noted a prevalent in vitro degradation of ...