Journal articleAuthors : Pantelejevs, Teodors (2023)
Stapling is a macrocyclisation method that connects amino
acid side chains of a peptide to improve its pharmacological properties.
We describe an approach for stapled peptide preparation and
biochemical evaluation that combines recombinant expression of
fusion constructs of target peptides and cysteine-reactive divinylheteroaryl
chemistry, as an alternative to solid-phase synthesis. We
then employ this workflow to prepare and evaluate BRC-repeatderived
... 
