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Browsing by Subject Serine protease inhibitor

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  • OER000000718.pdf.jpg
  • Journal article

  • Serpins: Purification and characterization of potent protease inhibitors from Clostridium thermocellum

    • Authors : Mushtaq, Maria; Asad, Muhammad Javaid; Hyder, Muhammad Zeeshan (2020)

  • Clostridium thermocellum produces an extracellular cellulosome (a multiprotein complex produced by firmicutes bacteria), which, owing to its extracellular location, is open to protease attack. Serine protease inhibitors (serpins) protect bacteria against protease attack. However, their structure and function are poorly characterized. This study identified and amplified the serpin 1270 gene from the C. thermocellum genome. Purified serpins were cloned into the pTXB1 vector u...
  • OER000000364.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Structural modeling and thermostability of a serine protease inhibitor belonging to the Kunitz family from the tick Rhipicephalus microplus

    • Authors : Camillo, Lívia de Moraes Bomediano; Ferreira1, Graziele Cristina; Feliciano, Adriana (2020)

  • rBmTI-A is a recombinant serine protease inhibitor that belongs to the Kunitz-BPTI family and that was cloned from Rhipicephalus microplus tick. rBmTI-A has inhibitory activities on bovine trypsin, human plasma kallikrein, human neutrophil elastase and plasmin with dissociation constants in nM range. It is characterized by two inhibitory domains and each domain presents six cysteines that form three disulfide bonds, which contribute to the high stability of&#...