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  • OER000000779.pdf.jpg
  • Journal article

  • Structural features of an infectious recombinant PrPSc prion using solid state NMR

    • Authors : Pastor, Manuel Martín; Codeseira, Yaiza B; Spagnolli, Giovanni (2020)

  • PrPSc, the first described and most notorious prion, is the only protein known to cause epidemics of deadly disease. Its properties are encoded in its unique structure. Here we report a first solid state NMR study of a uniformly labelled (U-13C,15N)-Bank vole (BV) infectious recombinant PrPSc prion. C-C, C-H and N-H spectra were obtained with MAS rotation of the sample at up to 60 kHz. We obtained amino acid-type secondary structure i...
  • OER000000367.pdf.jpg
  • Periodicals (Báo – Tạp chí)

  • Structure of the yeast Nup84-Nup133 complex details flexibility and reveals universal conservation of the membrane anchoring ALPS motif

    • Authors : Nordeen, Sarah A; Turman, Daniel L; Schwartz, Thomas U (2020)

  • The hallmark of the eukaryotic cell is the complex endomembrane system that compartmentalizes cellular functions. Transport into and out of the nucleus, occurs through the Nuclear Pore Complex (NPC). The heptameric Nup84 or Y complex is an essential scaffolding component of the NPC. Here we report two nanobody-bound structures: the full-length Nup84-Nup133 C-terminal domain complex and the Nup133 N-terminal domain, both from S. cerevisiae. Together with previ...