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  • OER000002983.pdf.jpg
  • Journal article

  • The human GID complex engages two independent modules for substrate recruitment

    • Authors : Mohamed, Weaam I. (2021)

  • The human GID (hGID) complex is an evolutionary conserved E3 ubiquitin ligase regulating diverse biological processes including glucose metabolism and cell cycle progression. However, the biochemical function and substrate recognition of the multi-subunit complex remains poorly understood. While the yeast GID complex recognizes Pro/N-end rule substrates via yeast Gid4, the human GID complex requires a WDR26/Gid7-dependent module to trigger proteasomal&#x...