Journal articleAuthors : Bae, Hwan (2023)
Previously, we reported that the conformation of autoinhibited Akt, a Ser/Thr protein kinase that
plays a central role in metabolism and cancer, may be shifted by small molecule allosteric inhibitors
limiting the mechanistic insights from existing X-ray structures that have relied on such compounds
(Chu, Viennet, et al, 2020). Here we discover unexpectedly that a single mutation, R86A, in Akt’s PH
domain exhibits intensified autoinhibitory&... 
