Duyệt theo

Hồ sơ tác giả

Tìm kiếm theo: Chủ đề Tinh thể học

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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  • OER000002591.pdf.jpg
  • Journal article

  • Ambient temperature crystal structure of Escherichia coli CyaY protein displays alternate conformation

    • Tác giả : Shafiei, Alaleh (2023)

  • Frataxin is a 23 KDa mitochondrial iron-binding protein that is involved in biogenesis of iron sulfur clusters. A deficiency in frataxin leads to Friedreich's ataxia, a progressive neurodegenerative disorder. The bacterial ortholog of eukaryotic mitochondrial frataxin, CyaY, is thought to play a role in iron sulfur cluster assembly as an iron supplier, making it an important target for study. Here, we present the first ambient tem...
  • OER000002345.pdf.jpg
  • Journal Article

  • Cooperative conformational transitions and the temperature dependence of enzyme catalysis

    • Tác giả : Walker, Emma J. (2023)

  • Many enzymes display non-Arrhenius behaviour with curved Arrhenius plots in the absence of denaturation. There has been significant debate about the origin of this behaviour and recently the role of the activation heat capacity (Δ𝐶# ‡) has been widely discussed. If enzymecatalysed reactions occur with appreciable negative values of Δ𝐶# ‡ (arising from narrowing of the conformational space along the reaction coordinate), then curved ...