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  • OER000002388.pdf.jpg
  • Journal Article

  • Structural Basis for Autoinhibition by the Dephosphorylated Regulatory Domain of Ycf1

    • Authors : Khandelwal, Nitesh Kumar (2023)

  • Yeast Cadmium Factor 1 (Ycf1) sequesters glutathione and glutathione-heavy metal conjugates into yeast vacuoles as a cellular detoxification mechanism. Ycf1 belongs to the C subfamily of ATP Binding Cassette (ABC) transporters characterized by long flexible linkers, notably the regulatory domain (R-domain). R-domain phosphorylation is necessary for activity, whereas dephosphorylation induces autoinhibition through an undefined mechanism. Because of its transient and dynamic nature,&#...