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Showing results 1 to 3 of 3
  • OER000002725.pdf.jpg
  • Journal article

  • Antisense pairing and SNORD13 structure guide RNA cytidine acetylation

    • Authors : Gamage, Supuni Thalalla (2023)

  • N4-acetylcytidine (ac4C) is an RNA nucleobase found in all domains of life. Establishment of ac4C in helix 45 (h45) of human 18S ribosomal RNA (rRNA) requires the combined activity of the acetyltransferase NAT10 and the box C/D snoRNA SNORD13. However, the molecular mechanisms governing RNA-guided nucleobase acetylation in humans remain unexplored. Here we report two assays that enable the study of SNORD13-dependent RNA acetylation in human cells. F...
  • OER000002538.pdf.jpg
  • Journal article

  • Epigenetic mechanisms to propagate histone acetylation by p300/CBP

    • Authors : Kikuchi, Masaki  (2023)

  • Histone acetylation is important for the activation of gene transcription but little is known 14 about its direct ‘read/write’ mechanisms. Here, we report cryo-electron microscopy structures 15 in which a p300/CBP multidomain monomer recognizes histone H4 N-terminal tail (NT) 16 acetylation (ac) in a nucleosome and acetylates non-H4 histone NTs within the same 17 nucleosome. p300/CBP not only recognized H4NTac via the bromodomain pocke...
  • OER000002389.pdf.jpg
  • Journal Article

  • Site-specific acetylation of polynucleotide kinase 3’-phosphatase (PNKP) regulates its distinct role in DNA repair pathways

    • Authors : Islam, Azharul (2023)

  • Mammalian polynucleotide kinase 3’-phosphatase (PNKP) is a dual-function DNA endprocessing enzyme with 3’-phosphatase and 5’-kinase activities, which generate 3’-OH and 5’- phosphate termini respectively, as substrates for DNA polymerase and DNA ligase to complete DNA repair. PNKP is thus involved in multiple DNA repair pathways, including base excision (BER), single-strand break (SSBR), and double-strand break repair (DSBR). However, little is known as&...