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Journal Article

SARS-COV-2 Spike Protein Fragment eases Amyloidogenesis of α-Synuclein

Authors : Chesney, Andrew D (2023)

Parkinson’s Disease is accompanied by presence of amyloids in the brain formed of α-synuclein chains. Correlation between COVID-19 and the onset of Parkinson’s disease let to the idea that amyloidogenic segments in SARS-COV-2 proteins can induce aggregation of α-synuclein. Using molecular dynamic simulations, we show that the fragment FKNIDGYFKI of the spike protein, which is unique for SARS-COV-2, shifts preferentially the ensemble of α-synuclein&#x...

Ebooks (Sách điện tử)

The folding-limited nucleation of curli hints at an evolved safety mechanism for functional amyloid production

Authors : Claridge, Jolyon K. (2023)

It is nearly two decades ago that the ‘thin aggregative fimbriae’ which had been shown to enhance the biofilm formation of Salmonella enteriditis and Escherichia coli were identified as amyloid fibers. The realization that natural proteins can develop amyloidogenic traits as part of their functional repertoire instigated a search for similar proteins across all kingdoms of life. That pursuit has since unearthed dozens of candidates which&#x...