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Showing results 1 to 2 of 2
  • OER000002282.pdf.jpg
  • Journal Article

  • Acetic acid is a superior acidifier for sub-nanogram and single cell proteomic studies

    • Authors : Orsburn, Benjamin C (2023)

  • Amyloid β (Aβ) peptides accumulating in the brain are proposed to trigger Alzheimer's disease (AD). However, molecular cascades underlying their toxicity are poorly defined. Here, we explored a novel hypothesis for Aβ42 toxicity that arises from its proven affinity for γ-secretases. We hypothesized that the reported increases in Aβ42, particularly in the endolysosomal compartme...
  • OER000002542.pdf.jpg
  • Industry article

  • Bi-functional particles for real-time acidification and proteolysis multiplex assay in macrophages

    • Authors : Alejandre, Alba Méndez (2023)

  • Phagosome acidification and proteolysis are essential processes in the immune response to contain and eliminate pathogens. In recent years, there has been an increased desire for a rapid and accurate method of assessing these processes in real-time. Here, we outline the development of a multiplexed assay that allows simultaneous monitoring of phagosome acidification and proteolysis in the same sample using silica beads conjugated to pHrodo...