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  • OER000002990.pdf.jpg
  • Journal article

  • A common polymorphism that protects from cardiovascular disease increases fibronectin processing and secretion

    • Authors : Soubeyrand, Sébastien (2021)

  • Fibronectin (FN1) is an essential regulator of homodynamic processes and tissue remodeling which has been proposed to contribute to atherosclerosis. Moreover, recent large scale genome wide association studies have linked common genetic variants within the FN1 gene to coronary artery disease (CAD) risk. Genome-wide Association Studies (GWAS) have identified hundreds of common single nucleotide polymorphisms (SNPs) that associate with cardiovascular disease (CA...
  • OER000002581.pdf.jpg
  • Journal article

  • Adiponectin Reverses β-Cell Damage and Impaired Insulin Secretion Induced by Obesity

    • Authors : Munhoz, Ana Cláudia (2023)

  • Obesity significantly decreases life expectancy and increases the incidence of age-related dysfunctions, including -cell dysregulation leading to inadequate insulin secretion. Here, we show that diluted plasma from obese human donors acutely impairs -cell integrity and insulin secretion relative to plasma from lean subjects. Similar results were observed with diluted sera from obese rats fed ad libitum, when compared to sera from lean, calorically-restricted, animals....