Journal ArticleAuthors : Maharana, Jagannath (2023)
β-arrestins are multifunctional proteins that are critically involved in regulating spatio26
temporal aspects of GPCR signaling. The interaction of β-arrestins with GPCRs is typically
conceptualized in terms of receptor activation and phosphorylation primarily in the carboxyl
terminus. Interestingly however, there are several GPCRs that harbor majority of
phosphorylation sites in their 3rd intracellular loop (ICL3) instead of carboxyl-terminus but still
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