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Ebooks (Sách điện tử)

A marine cryptochrome with an inverse photo-oligomerization mechanism

Authors : Vu, Hong Ha (2023)

Cryptochromes (CRYs) are a structurally conserved but functionally diverse family of proteins that can confer unique sensory properties to organisms. In the marine bristle worm Platynereis dumerilii, its light receptive cryptochrome L-CRY (PdLCry) allows the animal to discriminate between sunlight and moonlight, an important requirement for synchronizing its lunar cycledependent mass spawning. Using cryo-electron microscopy, we show that in the dark, PdLCry&#x...

Ebooks (Sách điện tử)

Characterizing glucokinase variant mechanisms using a multiplexed abundance assay

Authors : Gersing, Sarah (2023)

Amino acid substitutions can perturb protein activity in multiple ways. Understanding 14 their mechanistic basis may pinpoint how residues contribute to protein function. Here, we 15 characterize the mechanisms of human glucokinase (GCK) variants, building on our previous 16 comprehensive study on GCK variant activity. We assayed the abundance of 95% of GCK 17 missense and nonsense variants, and found that 43% of hypoactive variants have&#x...

Journal article

Decoding the Dual Recognition Mechanism of Glucocorticoid Receptor for DNA and RNA: Sequence vs. Shape

Authors : Johanna, Hörberg (2023)

Transcription factors (TFs) regulate eukaryotic transcription through selecting DNA-binding, can also specifically interact with RNA, which may present another layer of transcriptional control. The mechanisms of the TFs-DNA recognition are often well-characterised, while the details of TFs-RNA complexation are less understood. Here we investigate the dual recognition mechanism of the glucocorticoid receptor (GR), which interacts with similar affinities with consen...

Ebooks (Sách điện tử)

Exploring the Chain Release Mechanism from an Atypical Apicomplexan Polyketide Synthase

Authors : Keeler, Aaron M. (2023)

Polyketide synthases (PKSs) are megaenzymes that form chemically diverse polyketides and are found within the genomes of nearly all classes of life. We recently discovered the type I PKS from the apicomplexan parasite Toxoplasma gondii, TgPKS2, which contains a unique putative chain release mechanism that includes ketosynthase (KS) and thioester reductase (TR) domains. Our bioinformatic analysis of the thioester reductase of TgPKS2, TgTR, suggests differences in&#...

Industry article

Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease

Authors : gerber, janina Lara (2023)

RNA ligases of the RTCB-type play an essential role in tRNA splicing, the unfolded protein response and RNA repair. RTCB is the catalytic subunit of the pentameric human tRNA ligase complex. RNA ligation by the tRNA-ligase complex requires GTP-dependent activation of RTCB. This active site guanylylation reaction relies on the activation factor Archease. The mechanistic interplay between both proteins has remained unknown. Here, we report a&...