Digital resources - Ha Noi university of science and technology

Browsing by Subject chất đạm

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:

Showing results 1 to 2 of 2

Journal Article

Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein

Authors : Mortelecque, Justine (-)

VHHs (Variable Heavy-chain of the Heavy-chain-only antibodies), also named single domain antibodies or nanobodies (1), are the smallest domains of natural Camelidae single chain antibodies that are still capable to recognize an antigen. Their many interesting properties and potential for engineering make VHHs ideal candidates for the design of innovative treatments (2) and new investigation tools (3, 4), including for in-cell imaging (5). Their ...

Journal article

Structure and dynamics of a cold-active esterase reveals water entropy and active site accessibility as the likely drivers for cold-adaptation

Authors : Noby, Nehad (2021)

Cold-active esterases hold great potential for undertaking useful biotransformations at low temperatures. Here, we determined the structure of a cold active family IV esterase (EstN7) cloned from Bacillus cohnii strain N1. EstN7 is a dimer with a classical a/b hydrolase fold. It has an acidic surface that is thought to play a role in cold-adaption by retaining solvation under changed water solvent entropy at lower&#x...