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Showing results 1 to 4 of 4
  • OER000002949.pdf.jpg
  • Journal article

  • An experimentally-derived measure of inter-replicate variation in reference samples: the same-same permutation methodology

    • Authors : Handler, David C. (2021)

  • The multiple testing problem is a well-known statistical stumbling block in high-25 throughput data analysis, where large scale repetition of statistical methods introduces 26 unwanted noise into the results. While approaches exist to overcome the multiple testing 27 problem, these methods focus on theoretical statistical clarification rather than incorporating 28 experimentally-derived measures to ensure appropriately tailored analysis parameters. Here, 29 we introduce a m...
  • OER000002757.pdf.jpg
  • Journal article

  • Clearing of ribosome collisions by the ribosome quality control trigger complex RQT

    • Authors : Best, Katharina (2023)

  • After translational stalls, colliding eukaryotic ribosomes are cleared through dissociation into subunits by the ribosome quality control trigger complex, RQT, by an unknown mechanism. Here we show that RQT requires accessible mRNA and the presence of a neighboring ribosome. Cryo-EM of several RQT-ribosome complexes revealed the structural basis of splitting: RQT engages the 40S subunit of the lead ribosome and can switch between two conformations. We propose...