Journal articleAuthors : Pedram, Kayvon (2023)
Targeted protein degradation is an emerging strategy for the elimination of classically
undruggable proteins. Here, to expand the landscape of substrates that can be selectively
degraded, we designed degraders which are dependent on both peptide sequence and
glycosylation status of the target protein. We applied this approach to mucins, O-glycosylated
proteins that drive cancer progression through biophysical and immunological mechanisms.
Engineering of&... 
