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Journal Article

Factors influencing the detergent-free membrane protein isolation using synthetic nanodisc-forming polymers

Authors : Krishnarjuna, Bankala (2023)

The detergent-free isolation of membrane proteins using synthetic polymers is becoming the desired approach for functional and structural studies of membrane proteins. Since the expression levels for many membrane proteins are low and a high yield of functionalized reconstituted membrane proteins is essential for in vitro studies, it is crucial to optimize the experimental conditions for a given polymer to effectively solubilize target membranes/...

Journal Article

The bigger picture: global analysis of solubilization performance of classical detergents versus new synthetic polymers utilizing shotgun proteomics

Authors : Mueller, Stefan (2023)

Integral membrane proteins are critical for many cellular functions. Roughly 25% of all human genes 12 code for membrane proteins, and about 70% of all approved drugs target them. Despite their 13 importance, laborious and harsh purification conditions often hinder their characterization. 14 Traditionally, they are removed from the membrane using detergents, thereby taking the proteins out 15 of their native environment, affecting their function. Recently, a&...