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  • OER000002999.pdf.jpg
  • Journal article

  • Electron transfer parameters for Methemoglobin formation in mutant Hemoglobin α-chains

    • Authors : Dixit, Vaibhav A. (2021)

  • Hemoglobin mediated transport of dioxygen (O2) critically depends on the stability of the reduced (Fe2+) form of the Heme cofactors. Some protein mutations stabilize oxidized (Fe3+) state (Methemoglobin, Hb M) causing methemoglobinemia and can be lethal above 30 %. Majority of the analyses of factors influencing Hb oxidation are retrospective and give insights only for inner sphere mutations of Heme (His58, His87). Herein, we report the first all at...