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Showing results 1 to 5 of 5
  • OER000000337.pdf.jpg
  • Book

  • Bioeconomy: Shaping the Transition to a Sustainable, Biobased Economy

    • Authors : Iris Lewandowski (2018)

  • Part I Bioeconomy Concepts and Research Methods: Bioeconomy Concepts, Inter- and Transdisciplinarity in Bioeconomy. Part II Knowledge Base for Biobased Value Chains: Biobased Resources and Value Chains, Primary Production, Processing of Biobased Resources, Markets, Sustainability Management and Entrepreneurship. Part III Transition to a Sustainable Bioeconomy: Modelling and Tools Supporting the Transition to a Bioeconomy, Environmental Economics, the Bioeconomy and the Role of G...
  • OER000002748.pdf.jpg
  • Journal article

  • Computationally Guided Design of Novel Angiotensin Converting Enzyme Inhibitors

    • Authors : Lam, Jennifer D. (2023)

  • Angiotensin-converting enzyme inhibitors (ACEI) such as Moexipril, Trandolapril, Ramipril, and Perindopril are used to treat hypertension. However, these drugs have undesired side effects. Using computational studies, two new novel drug candidates were designed with improved molecular interactions, ADMET properties, and docking scores compared to Moexipril. Homology analysis was done to determine the best animal model for preclinical studies, and it revealed that Pan troglo...
  • OER000002503.pdf.jpg
  • Journal article

  • Identification of a new Corin atrial natriuretic peptide-converting enzyme substrate: Agouti-signaling protein (ASIP)

    • Authors : MacDonald, Bryan T.  (2023)

  • Corin is a transmembrane tethered enzyme best known for processing the hormone atrial natriuretic peptide (ANP) in cardiomyocytes to control electrolyte balance and blood pressure. Loss of function mutations in Corin prevent ANP processing and lead to hypertension. Curiously, Corin loss of function variants also result in lighter coat color pigmentation in multiple species. Corin pigmentation effects are dependent on a functional Agouti locus encoding the ago...
  • OER000002493.pdf.jpg
  • Journal Article

  • PROTEOMICS OF HYPOTHERMIC ADAPTATION REVEALS THAT RBM3 ENHANCES MITOCHONDRIAL METABOLISM AND MUSCLE STEM-CELL DIFFERENTIATION

    • Authors : Dey, Paulami  (2023)

  • Adaptation to hypothermic stress is important for skeletal muscle cells, but a 17 comprehensive knowledge of molecular mediators is lacking. We show that adaptation to 18 mild hypothermia (320C) improves the ability of skeletal muscle myoblasts to differentiate 19 into myotubes in vitro. We performed proteomic analysis of mouse myoblasts exposed to 20 mild hypothermia for various time points and identified dynamic changes in 21 mitochondrial metabolism a...
  • OER000002973.pdf.jpg
  • Journal article

  • Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD (14/96/109)

    • Authors : Perera, Luke A. (2021)

  • The endoplasmic reticulum (ER) Hsp70 chaperone BiP is regulated by AMPylation, a reversible inactivating post-translational modification. Both BiP AMPylation and deAMPylation are catalysed by a single ER-localised enzyme, FICD. Here we present long-sought crystallographic and solution structures of a deAMPylation Michaelis complex formed between mammalian AMPylated BiP and FICD. The latter, via its tetratricopeptide repeat domain, binds a surface that is specific&#x...