Journal articleAuthors : Cheng, Jingdong (2021)
Assembly of the mitoribosome is largely enigmatic and involves numerous assembly
factors. However, little is known about their function and the architectural transitions
of the pre-ribosomal intermediates. Here, we solved cryo-EM structures of the human
39S large subunit pre-ribosomes, representing four distinct late state intermediates.
Besides the MALSU1 complex, we identified several assembly factors, including the
DDX28 helicase, MRM3, GTPBP10 and th... 
