- Journal article
Authors : Almasy, Katherine M. (2021) - Human coronaviruses have become an increasing threat to global health; three highly pathogenic strains have emerged since the early 2000s, including most recently SARS-CoV-2, the cause of COVID-19. A better understanding of the molecular mechanisms of coronavirus pathogenesis is needed, including how these highly virulent strains differ from those that cause milder, common-cold like disease. While significant progress has been made in understanding how SARS-CoV-2 ...
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- Journal article
Authors : Kentaka, Aruga (2022) - This study investigated how the changes in the number of people’s visits to various locations
during the COVID-19 pandemic influenced electricity demand. Using the autoregressive distributed
lag (ARDL) model, the study reveals that while an increase in visits to groceries, pharmacies stores,
and transit stations increased electricity demand, an increase in the hours people spent at home had a
negative impact on the demand during the pe...
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- Journal article
Authors : Muckenfuss, Lena M. (2023) - 3’ end formation of most eukaryotic mRNAs is dependent on the assembly of a ~1.5 megadalton
3 multiprotein complex, that catalyzes the coupled reaction of pre-mRNA cleavage and polyadenylation.
4 In mammals, the cleavage and polyadenylation specificity factor (CPSF) constitutes the core of the
5 3’ end processing machinery onto which the remaining factors, including cleavage stimulation factor
6 (CstF) and poly(A) polymerase (PAP), assemble....
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- Journal article
Authors : Dannenberg, Rachel L. (2023) - During DNA replication, DNA lesions present in lagging strand templates are initially encountered by DNA polymerase (pol ). The historical view for what transpires from these encounters is that replication of the afflicted lagging strand template abruptly stops, activating DNA damage tolerance (DDT) pathways that replicate the offending lesion and adjacent DNA sequence, allowing pol to resume downstream. However, qualitative studies observed that human p...
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- Journal article
Authors : Ragotte, Robert J. (2021) - Basigin, or CD147, has been reported as a co-receptor used by SARS-CoV-2 to invade host cells. Basigin also has a well-established role in Plasmodium falciparum malaria infection of human erythrocytes where it is bound by one of the parasite’s invasion ligands, reticulocyte binding protein homolog 5 (RH5). Here, we sought to validate the claim that the receptor binding domain (RBD) of SARS-CoV-2 spike glycoprotein can form a complex with basigi...
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- Ebooks (Sách điện tử)
Authors : Grewal, Mandeep; Wakim, Suzanne (2023) - -
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- Journal article
Authors : Prieto, Mercedes Alfonso (2023) - Atomistic-level investigation of olfactory receptors (ORs) is a challenging task due
to the experimental/computational difficulties in the structural determination/prediction
for members of this family of G-protein coupled receptors. Here we have developed
a protocol that performs a series of molecular dynamics simulations from a set of
structures predicted de novo by recent machine learning algorithms and apply it to
a well-studied receptor,&#...
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- Journal article
Authors : Mathias, Rieder (2019) - Finding staff for carrying out logistic tasks is getting harder and harder for companies as a survey of Kohl and Pfretzschner (2017) showed. Combined with developments in engineering and Artificial Intelligence there is a trend to integrate machines into the execution of logistic tasks, either to support workers or to automate them completely (Schneider, et al. 2018). Different to tasks for transport or manufacturing standardization, ...
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- Journal article
Authors : Bonelli, Roberto (2023) - The primate retina has evolved regional specialisations for specific visual functions. The macula is specialised towards high acuity vision and is an area that contains an increased density of cone photoreceptors and signal processing neurons. Different regions in the retina display unique susceptibility to pathology, with many retinal diseases primarily affecting the macula. To better understand the properties of different retinal areas we conducted an untargeted...
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- Industry article
Authors : gerber, janina Lara (2023) - RNA ligases of the RTCB-type play an essential role in tRNA splicing, the unfolded protein response
and RNA repair. RTCB is the catalytic subunit of the pentameric human tRNA ligase complex. RNA
ligation by the tRNA-ligase complex requires GTP-dependent activation of RTCB. This active site
guanylylation reaction relies on the activation factor Archease. The mechanistic interplay between
both proteins has remained unknown. Here, we report a&...
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- Journal article
Authors : Sim, Sue Im (2021) - Polyamines are small, organic polycations that are ubiquitous and essential to all forms of life. Currently,
how polyamines are transported across membranes is not understood. Recent studies have suggested
that ATP13A2 and its close homologs, collectively known as P5B-ATPases, are polyamine transporters at
endo-/lysosomes. Loss-of-function mutations of ATP13A2 in humans cause hereditary early-onset
Parkinson’s disease. To understand the polyamine ...
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- Journal article
Authors : Yadav, Manish K. (2023) - The complement cascade is an integral part of innate immunity, and it plays a crucial role in our body's innate immune response including combating microbial infections. Activation of the complement cascade results in the generation of multiple peptide fragments, of which complement C3a and C5a are potent anaphylatoxins. The complement C3a binds and activates a G protein-coupled receptor (GPCR) known as C3aR while C5a activates two distinct receptors...
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- Journal article
Authors : Hussain, Nazia (2023) - Pannexins are single-membrane large-pore ion channels that release ATP upon
activation. Three isoforms of pannexins, 1, 2, and 3, perform diverse cellular roles, including
inflammation, differentiation, neuropathic pain, and ATP release. In this study, we report the
cryoEM structure of pannexin 3 at 3.9 Å and characterize the structural differences with
pannexin isoforms 1 and 2. We observe the organization of the Pannexin 3 vestibule into&...
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- Ebooks (Sách điện tử)
Authors : Lewis, Richard S. (2021) - We are immersed in a world mediated by information and communication
technologies (ICTs), both hardware (smartphones, smartwatches,
home assistants) and software (algorithms, software programs, and
infrastructures such as Facebook, Instagram, Twitter, Snapchat). We
are transformed by these media, whether we have invited them into
our lives or not. We subsequently perceive and engage with the world
through these transformations. However, media liter...
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- Journal article
Authors : Mohamed, Weaam I. (2021) - The human GID (hGID) complex is an evolutionary conserved E3 ubiquitin ligase regulating diverse biological processes including glucose metabolism and cell cycle progression. However, the biochemical function and substrate recognition of the multi-subunit complex remains poorly understood. While the yeast GID complex recognizes Pro/N-end rule substrates via yeast Gid4, the human GID complex requires a WDR26/Gid7-dependent module to trigger proteasomal&#x...
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- Journal Article
Authors : Adiji, Olubu A. (2023) - The first step towards eukaryotic genome duplication is loading of the replicative helicase, the
Mcm2-7 complex, onto chromatin. This so-called “licensing” step is executed by the Pre-
Replication Complex (Pre-RC) whose assembly on chromatin is nucleated by the DNA-binding
activity of the Origin Recognition Complex (ORC). It is thought that metazoan ORC, like the yeast
complex, is recruited directly to chromatin by its ATP-dependent DNA bin...
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- Ebooks (Sách điện tử)
Authors : Jaksch, Dhaarsini (2023) - The mammalian tRNA ligase complex (tRNA-LC) catalyzes the splicing of intron-containing
pre-tRNAs in the nucleus and the splicing of XBP1 mRNA during the unfolded protein response
(UPR) in the cytoplasm. We recently reported that the tRNA-LC co-evolved with PYROXD1, an
essential oxidoreductase that protects the catalytic cysteine of RTCB, the catalytic subunit of
the tRNA-LC, against aerobic oxidation. In this study we show that the oxidore...
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- Book
Authors : Cvetković, Dragan (2021) - The introductory chapter presents the definitions and principles of VR, potential applications of VR and Augmented Reality (AR), and describes devices for VR. Chapter 2 clarifies the relationship between the body and the tangible or visible form of an idea, quality or feeling, in AR and VR, and the implications of essential-
ism, for the virtual sublime. Chapter 3 synthesizes recent studies into a set of educational design principles for&...
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