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  • OER000002463.pdf.jpg
  • Journal Article

  • Chemobiosis reveals tardigrade tun formation is dependent on reversible cysteine oxidation

    • Authors : Smythers, Amanda L. (2023)

  • Tardigrades, commonly known as ‘waterbears’, are eight-legged microscopic invertebrates renowned for their ability to withstand extreme stressors, including high osmotic pressure, freezing temperatures, and complete desiccation. Limb retraction and expelling their internal water stores results in the tun state, greatly increasing their ability to survive. Emergence from the tun state and/or activity regain follows stress removal, where resumption of life cycle occurs as...
  • OER000002963.pdf.jpg
  • Journal article

  • Cysteine crosslinking in native membranes establishes the transmembrane architecture of Ire1

    • Authors : Vaeth, Kristina (2021)

  • The endoplasmic reticulum (ER) is a key organelle of membrane biogenesis and crucial for the folding of both membrane and secretory proteins. Sensors of the unfolded protein response (UPR) monitor the unfolded protein load in the ER and convey effector functions for maintaining ER homeostasis. Aberrant compositions of the ER membrane, referred to as lipid bilayer stress, are equally potent activators of the UPR. How the distinct signals from li...
  • OER000002961.pdf.jpg
  • Journal article

  • Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization

    • Authors : Henning, Nathaniel J. (2021)

  • Targeted protein degradation is a powerful therapeutic modality that uses heterobifunctional small-molecules to induce proximity between E3 ubiquitin ligases and target proteins to ubiquitinate and degrade specific proteins of interest. However, many proteins are ubiquitinated and degraded to drive disease pathology; in these cases targeted protein stabilization (TPS), rather than degradation, of the actively degraded target using a smallmolecule would be ther...