Journal articleAuthors : Berríos, Kiara N. (2023)
The partnership of DNA deaminase enzymes with CRISPR-Cas nucleases is now a well-established method
to enable targeted genomic base editing. However, an understanding of how Cas9 and DNA deaminases
collaborate to shape base editor (BE) outcomes has been lacking. Here, we support a novel mechanistic
model of base editing by deriving a range of hyperactive activation-induced deaminase (AID) base editors
(hBEs) and exploiting their characteristic&#... 
