Duyệt theo

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Tìm kiếm theo: Chủ đề dị lập thể

Duyệt theo: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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  • OER000002413.pdf.jpg
  • Ebooks (Sách điện tử)

  • Differences in the regulation mechanisms of the glutamine synthetase from methanogenic archaea unveiled by structural investigations

    • Tác giả : Müller, Marie-Caroline (2023)

  • Glutamine synthetases catalyze the ATP-dependent ammonium assimilation, the initial step of nitrogen 18 acquisition that must be tightly regulated to fit cellular needs. While their catalytic mechanisms and 19 regulation are well-characterized in bacteria and eukaryotes, only limited knowledge exists about the 20 archaeal representatives. Here, we natively purified the glutamine synthetases type I-α from 21 Methanothermococcus thermolithotrophicus and Methermicoccus shengliensis, two...
  • OER000002754.pdf.jpg
  • Journal article

  • SARS-CoV-2 spike variants differ in their allosteric response to linoleic acid

    • Tác giả : Oliveira, A. Sofia F. (2023)

  • The SARS-CoV-2 spike protein contains a fatty acid binding site, also found in some other coronaviruses (e.g. SARS-CoV), which binds linoleic acid and is functionally important. When occupied by linoleic acid, it reduces infectivity, by ‘locking’ the spike in a less infectious conformation. Here, we use dynamical-nonequilibrium molecular dynamics (D-NEMD) simulations to compare the response of spike variants to linoleic acid removal. These simulations show that&#x...
  • OER000002942.pdf.jpg
  • Journal article

  • Structure Activity Relationship of USP5 Allosteric Inhibitors

    • Tác giả : Mann, Mandeep K (2021)

  • USP5 is a deubiquitinase that has been implicated in a range of diseases, including cancer, but no USP5- targeting chemical probe has been reported to date. Here, we present the progression of a chemical series that occupies the C-terminal ubiquitin-binding site of a poorly characterized zinc-finger ubiquitin binding domain (ZnF-UBD) of USP5 and allosterically inhibits the catalytic activity of the enzyme. Systematic exploration of&...