Digital resources - Ha Noi university of science and technology

Browsing by Subject dịch mã

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:

Showing results 1 to 2 of 2

Journal article

N1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation

Authors : Monroe, Jeremy G. (2023)

rapid and accurate protein production. The inclusion of chemically modified bases into mRNAs has the potential to alter the strength and pattern of hydrogen bonding between mRNAs and aminoacyl-tRNAs to alter protein synthesis. We investigated how the N1-methylpseudouridine (m1Y) modification, commonly incorporated into therapeutic and vaccine mRNA sequences, influences the ability of codons to react with cognate and near-cognate tRNAs and release factors. We find ...

Journal article

Protein-Peptide Turnover Profiling reveals wiring of phosphorylation during protein maturation

Authors : Hammarén, Henrik M. (2023)

Post-translational modifications (PTMs) regulate various aspects of protein function, including degradation. Mass spectrometric methods that rely on pulsed metabolic labeling are very popular to quantify turnover rates on a proteome-wide scale. Such data have often been interpreted in the context of protein proteolytic stability. Here, we combine theoretical kinetic modeling with experimental pulsed stable isotope labeling of amino acids in cell culture&...