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Browsing by Subject fibronectin oncofetal

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  • OER000002355.pdf.jpg
  • Journal Article

  • Ubiquitin-derived artificial binding proteins targeting oncofetal fibronectin reveal scaffold plasticity by β-strand slippage

    • Authors :  Katzschmann, Anja (2023)

  • Affilin proteins (artificial binding proteins based on the ubiquitin scaffold) were generated using directed protein evolution to yield de‐novo variants that bind the extra‐domain B (EDB) of oncofetal fibronectin, an abundant tumor marker in fetal and neoplastic tissues. Structures of two EDB‐specific Affilin molecules reveal striking structural plasticity of the ubiquitin scaffold, characterized by β‐strand slippage, leading to diverse register shifts of ...