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Browsing by Subject folate

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Journal article

Cell-free Expression of Proton-Coupled Folate Transporter in the Presence of Nanodiscs

Authors : Do, Hoa Quynh (2021)

The Proton-Coupled Folate Transporter (PCFT) is a transmembrane transport protein that controls the absorption of dietary folates in the small intestine. PCFT also mediates uptake of chemotherapeutically used antifolates into tumor cells. PCFT has been identified within lipid rafts observed in phospholipid bilayers of plasma membranes, a micro environment that is altered in tumor cells. The present study aimed at investigating the ...

Journal article

Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity

Authors : Fiddler, Joanna L. (2023)

Serine hydroxymethyltransferase 2 (SHMT2) catalyzes the reversible conversion of 35 tetrahydrofolate (THF) and serine producing THF-conjugated one-carbon units and glycine in 36 the mitochondria. Biallelic SHMT2 variants were identified in humans and suggested to alter the 37 protein’s active site, potentially disrupting enzymatic function. SHMT2 expression has also been 38 shown to decrease with aging in human fibroblasts. Immortalized cells models of total SHMT2 39&#...