Browse

Author Profile

Browsing by Subject giải phóng

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 2 of 2
  • OER000002747.pdf.jpg
  • Journal article

  • Inhibiting succinate release worsens cardiac reperfusion injury by enhancing mitochondrial reactive oxygen species generation

    • Authors : Milliken, Alexander S. (2023)

  • The metabolite succinate accumulates during cardiac ischemia. Within 5 min. of 22 reperfusion, succinate returns to baseline levels via both its release from cells and oxidation by 23 mitochondrial complex II (Cx-II). The latter drives reactive oxygen species (ROS) generation and 24 subsequent opening of the mitochondrial permeability transition (PT) pore, leading to cell death. 25 Targeting succinate dynamics (accumulation/oxidation/release) may be therapeutically...
  • OER000002558.pdf.jpg
  • Journal article

  • Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments

    • Authors : Oosterheert, Wout (2023)

  • The release of inorganic phosphate (Pi) from actin filaments constitutes a key step in their regulated turnover, which is fundamental to many cellular functions. However, the molecular mechanisms underlying Pi release from both the core and barbed end of actin filaments remain unclear. Here, we combine cryo-EM with molecular dynamics simulations and in vitro reconstitution to demonstrate how actin releases Pi through a ‘molecular backdoor’. ...