Journal ArticleAuthors : Grassetti, andrew V (2023)
The application of support layers, such as graphene, to cryo-electron microscopy grids can increase the density
of particles imaged, limit particle interactions with the air-water interface, reduce the extent of beam-induced
motion, and, in some instances, improve the distribution of particle orientations. This paper describes a robust
protocol for coating cryo-EM grids with a monolayer of graphene for improved cryo-sample preparation. Single particle cryo...